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KMID : 1102020180480020033
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Applied Microscopy
2018 Volume.48 No. 2 p.33 ~ p.42
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Myosin X and Cytoskeletal Reorganization
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Ikebe Mitsuo
Sato Osamu
Sakai Tsuyoshi
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Abstract
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Myosin X is one of myosin superfamily members having unique cellular functions on cytoskeletal reorganization. One of the most important cellular functions of myosin X is to facilitate the formation of membrane protrusions. Since membrane protrusions are important factors for diverse cellular motile processes including cell migration, cell invasion, path-finding of the cells, intercellular communications and so on, it has been thought that myosin X plays an important role in various processes that involve cytoskeletal reorganization including cancer progression and development of neuronal diseases. Recent studies have revealed that the unique cellular function of myosin X is closely correlated with its unique structural characteristics and motor properties. Moreover, it is found that the molecular and cellular activities of myosin X are controlled by its specific binding partner. Since recent studies have revealed the presence of various specific binding partners of myosin X, it is anticipated that the structural, biochemical and cell biological understanding of the binding partner dependent regulation of myosin X function can uncover the role of myosin X in diverse cell biological processes and diseases.
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KEYWORD
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Myosin X, Motor proteins, Processive movement, Membrane protrusions, Cytoskeletal structure
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